Tetanus Toxin.
نویسندگان
چکیده
منابع مشابه
Cell surface-exposed tetanus toxin fragment C produced by recombinant Bacillus anthracis protects against tetanus toxin.
Bacillus anthracis, the causal agent of anthrax, synthesizes two surface layer (S-layer) proteins, EA1 and Sap, which account for 5 to 10% of total protein and are expressed in vivo. A recombinant B. anthracis strain was constructed by integrating into the chromosome a translational fusion harboring the DNA fragments encoding the cell wall-targeting domain of the S-layer protein EA1 and tetanus...
متن کاملStructure of Tetanus Toxin DEMONSTRATION AND SEPARATION OF A SPECIFIC ENZYME CONVERTING INTRACELLULAR TETANUS TOXIN
Protease activity has been demonstrated in culture supernatants of Clostridium tetani at various stages of fermentation. Gel chromatography of the concentrated filtrates revealed the presence of three enzymatically active fractions eluting at separate positions off the column. The smallest protease was found to “nick” the single chain intracellular tetanus toxin, producing the extracellular, tw...
متن کاملToxin-neutralizing effect of antibody against subtilisin-digested tetanus toxin.
A form of systemic tetanus with atypical symptoms was observed in mice injected in the left thigh with a mixture of tetanus toxin and antibody produced in guinea pigs against a fragment of toxin obtained from a subtilisin digest of the crystallized toxin. The mice did not show typical symptoms of the local tetanus such as convulsions or spastic paralysis of the injected limb.
متن کاملThe complete nucleotide sequence of tetanus toxin.
We have previously isolated and sequenced a portion of the structural gene for tetanus toxin from C.tetani CN3911 (1). Overlapping clones encoding the entire gene have now been isolated and the full sequence is reported below. Our designation of the start of translation is based on amino terminal analysis (2) and partial ami no acid sequence of the toxin (3). The methionine residue before the p...
متن کاملThe Effect of Cysteine on Tetanus Toxin *
In the course of some experiments with tetanus toxin it was noted that cysteine, when added to the toxin with the intention of preserving it from oxidation, had, on the contrary, a deleterious effect. Other experiments showed that on diphtheria toxin there was but little effect, and on botulinus toxin and on ricin none at all. Locke and Maint have mentioned that cysteine can play a role in toxi...
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ژورنال
عنوان ژورنال: JAMA: The Journal of the American Medical Association
سال: 1895
ISSN: 0098-7484
DOI: 10.1001/jama.1895.02430110036014